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Mar 22 2018

How do seronegative and rheumatoid arthritis differ?

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How do seronegative and rheumatoid arthritis differ?


I have been recently diagnosed with sero-negative arthritis in my feet and toes.

I am keen to find out more about the condition and would like to know how sero-negative arthritis differs from rheumatoid arthritis.

My father had sero-negative arthritis, ankylosing spondylits, ulcerative colitis and Crohn’s disease.

He died eight years ago as a result of complications arising from his disorders.


Is there a possible genetic link between my father’s condition and my own?

I would greatly appreciate any advice you could offer, as my doctors are not forthcoming with regards to information or understanding about my arthritis.

I feel left in the dark, with little option other than to blindly agree to take the drugs that are offered to me.


Sero-negative arthritis is relatively common and it may result from having a range of conditions that include gout. ulcerative colitis. Crohn’s disease. psoriasis. Reiter’s and ankylosing spondylitis.

Sero-negative conditions are those in which the blood tests for rheumatoid arthritis are negative; they are very much more common in males than females.

Usually, there is involvement of asymmetrical large joints, or just one joint.

If the spine is painful, it is well worth doing a test to exclude ankylosing spondylitis, which is associated with an abnormality in the HLA B27 test in about 90 per cent of cases.

There may be aches and pains, in the soles of the feet or in the achilles tendons at the heels for example.

Usually the treatment will involve activity, and using the joints unless they are hot and inflamed.

Taking anti-inflammatory treatments will ease the pain. The physiotherapist or chiropractor may be of considerable help to you.

It may be that there is a genetic component to your condition and it sounds as if you need to be told exactly what the condition is that you have been suffering from.

Do ask your doctor to tell you more about your arthritis, and precisely what is wrong.

It is possible that he has been unable to make an exact diagnosis, since it is sometimes extremely difficult to do so when young women suffer from the milder forms of sero-negative arthritis.

If you are suffering, and worrying, do talk to your GP. If necessary, he/she will send you to a specialist in rheumatology to plan your treatment options for the future.

The NetDoctor Medical Team

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